Methylation, a biochemical process essential to human health, has gained significant attention for its role in longevity. This intricate process involves the transfer of a methyl group (one carbon atom and three hydrogen atoms) to various molecules within the body. This seemingly simple action has profound implications for DNA repair, gene expression, detoxification, and overall cellular function. In this blog, we will explore the importance of methylation in promoting longevity, drawing on insights from Dr. Mark Hyman, Chris Masterjohn, and Thorne Supplements.

Understanding Methylation and Its Impact

Methylation occurs billions of times per second in the human body, influencing a wide range of physiological processes. One of its key roles is in the regulation of gene expression, which impacts how our genes are turned on and off. This process is crucial for maintaining healthy cellular function and preventing the onset of diseases associated with aging, such as cancer and cardiovascular disease.

Dr. Mark Hyman, a leading expert in functional medicine, emphasizes the importance of optimal methylation for overall health and longevity. According to Dr. Hyman, impaired methylation can lead to a variety of health issues, including inflammation, poor detoxification, and increased risk of chronic diseases. By supporting methylation, we can enhance our body’s ability to repair DNA, maintain healthy cell function, and improve resilience against age-related diseases.

Chris Masterjohn, a well-known researcher in the field of nutritional sciences, also highlights the significance of methylation. Masterjohn points out that methylation is not only vital for DNA synthesis and repair but also for neurotransmitter production and energy metabolism. He underscores the importance of a balanced diet and targeted supplementation to support methylation pathways.

Assessing Methylation Status

Assessing your methylation status is a crucial step in understanding and optimizing this process for better health and longevity. Here are some common methods:

  1. Homocysteine Levels: Elevated homocysteine levels can indicate poor methylation. A simple blood test can measure your homocysteine levels, providing insight into your methylation efficiency.
  2. Genetic Testing: Certain genetic variations, such as MTHFR mutations, can impact methylation. Genetic testing can identify these variations, helping to tailor personalized interventions.
  3. Methylation Panels: Specialized tests can measure the activity of enzymes involved in methylation and the levels of specific methylation markers. These panels offer a comprehensive view of your methylation status.
  4. Nutrient Testing: Assessing levels of vitamins and minerals that support methylation, such as B vitamins and magnesium, can provide indirect insights into your methylation health.

The Role of Supplements in Supporting Methylation

To optimize methylation, it’s essential to ensure adequate intake of key nutrients that support this process. These include:

  • Folate (Vitamin B9): Essential for DNA synthesis and repair. Folate is found in leafy greens, legumes, and fortified foods.
  • Vitamin B12: Works in tandem with folate to support methylation. B12 is found in animal products such as meat, dairy, and eggs.
  • Vitamin B6: Involved in over 100 enzymatic reactions, including those related to methylation. B6 is found in fish, poultry, potatoes, and non-citrus fruits.
  • Betaine (Trimethylglycine): Donates methyl groups to homocysteine, converting it to methionine, which is crucial for protein synthesis and methylation. Betaine is found in beets, spinach, and whole grains.

Thorne Supplements: Supporting Methylation

Thorne Supplements offers targeted solutions to support methylation and overall health. Thorne’s Methyl-Guard Plus is a well-known supplement that provides a comprehensive blend of folate, B12, B6, and betaine, specifically designed to optimize methylation pathways. This supplement is formulated to ensure that your body receives the necessary nutrients in bioavailable forms, enhancing their absorption and effectiveness.

Practical Tips for Enhancing Methylation

In addition to supplementation, there are several lifestyle changes you can make to support healthy methylation:

  1. Balanced Diet: Consume a diet rich in leafy greens, legumes, lean proteins, and whole grains to ensure adequate intake of methylation-supporting nutrients.
  2. Regular Exercise: Physical activity promotes healthy methylation and overall cellular function.
  3. Stress Management: Chronic stress can impair methylation. Practices such as mindfulness, meditation, and yoga can help reduce stress levels.
  4. Avoid Toxins: Minimize exposure to environmental toxins, which can disrupt methylation processes. Opt for organic foods and use natural cleaning products.


Methylation plays a vital role in maintaining cellular health and promoting longevity. By understanding the importance of this process and supporting it through targeted nutrition and lifestyle choices, we can enhance our overall well-being and resilience against age-related diseases. Insights from experts like Dr. Mark Hyman and Chris Masterjohn, along with the advanced formulations from Thorne Supplements, provide valuable resources for optimizing methylation and achieving a longer, healthier life.

Incorporating these strategies into your daily routine can make a significant difference in your long-term health. Embrace the power of methylation and take proactive steps towards a vibrant, longevity-focused lifestyle.


  1. Dr. Mark Hyman

    • Hyman, M. (2013). The Blood Sugar Solution 10-Day Detox Diet: Activate Your Body’s Natural Ability to Burn Fat and Lose Weight Fast. Little, Brown and Company.
    • Hyman, M. (2018). Food: What the Heck Should I Eat?. Little, Brown and Company.
    • Hyman, M. (2020). The Pegan Diet: 21 Practical Principles for Reclaiming Your Health in a Nutritionally Confusing World. Little, Brown and Company.
  2. Chris Masterjohn

    • Masterjohn, C. (2016). The Ultimate Cheat Sheet on Methylation. Retrieved from
    • Masterjohn, C. (2018). Everything You Need to Know About Methylation, in One Hour. Retrieved from
  3. Thorne Supplements

    • Thorne Research. (n.d.). Methyl-Guard Plus. Retrieved from
    • Thorne Research. (n.d.). The Role of Methylation in Health and Longevity. Retrieved from
  4. General Methylation Information

    • National Institutes of Health. (2020). Folate Fact Sheet for Health Professionals. Retrieved from
    • National Institutes of Health. (2020). Vitamin B12 Fact Sheet for Health Professionals. Retrieved from
    • Zeisel, S. H. (2006). Choline: Critical Role During Fetal Development and Dietary Requirements in Adults. Annual Review of Nutrition, 26, 229-250. DOI: 10.1146/annurev.nutr.26.061505.111156

By incorporating the knowledge from these experts and resources, you can better understand the vital role of methylation in promoting longevity and overall health.



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